Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing Research Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] abrupt onset Anxiety biological pathways CACNA1B candidate candidate gene categories category children Cohort conducted de novo Deleterious described disorder disrupting etiology European Evidence Exome expressed functional GABRG2 Genes Genetic variant Genetic variation GRIN2A heterogeneous identification immune functions Infection infections irritability microglia Mutation nervous system neuronal Neuropsychiatric NLRC4 pathological mechanism pediatric peripheral immune response PLCG2 PPM1D RAG1 regulate selected Sequencing SGCE SHANK3 Stressor subject swings Symptom syndrome SYNGAP1 union variant WES WGS whole genome [DOI] 10.1038/s41598-022-15279-3 [Article Type] Research
Multi-omic analysis reveals enriched pathways associated with COVID-19 and COVID-19 severity다중 오믹 분석은 COVID-19 및 COVID-19 심각성과 관련된 풍부한 경로를 보여줍니다Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition analyses Analysis analyzed approach biological pathway biological pathways Cell cell cycle characterized cholesterol clinical outcomes correlation correlations COVID-19 COVID-19 severity death disease disease severity disease status enriched pathway enrichment analysis hospital identify implicated Inflammatory response metabolic processes metabolomics molecular molecules Multiple observé Pathway analysis Patient predict principal components analysis proteomics reflected regression models reveal RNA sequencing data severity stability Symptoms the disease Vitamin was done with COVID-19 [DOI] 10.1371/journal.pone.0267047 PMC 바로가기 [Article Type] Article
Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19TrendCatcher를 사용한 임시 전사체 분석으로 심각한 COVID-19에서 조기 및 지속적인 호중구 활성화 식별Article Published on 2022-04-082022-09-11 Journal: JCI Insight [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation adaptive Analysis ANOVA bioinformatics biological pathway biological pathways biological processe biological processes Biomarker break point Cell Biology circulating cell Coagulation Course COVID-19 differentially expressed gene Disease progression Gene Expression gene signature hallmark identify IFN-I Immunity immunology individual Innate Innate immunity innate immunity. Longitudinal data mapped mechanism Mild neutrophil neutrophil activation Neutrophils pathogenic Pathways Patient Peripheral blood progressed progression provide R package receiving responses SARS-CoV-2 vaccination severe COVID-19 Signaling single-cell Temporal Temporal analysis therapeutic targets transcriptional transcriptomes transcriptomic analysis transcriptomic data Type I IFN [DOI] 10.1172/jci.insight.157255 PMC 바로가기 [Article Type] Article
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
Multitrait GWAS to connect disease variants and biological mechanismsMultitrait GWAS는 질병 변이체 및 생물학적 메커니즘을 연결합니다Research Article Published on 2021-08-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association biological pathway biological pathways breakdown Cluster common variants disease drug target Focusing functional gene cluster genetic architecture genetic association genetic associations Genetic variant genetic variants Genome-wide association studies GWAS GWAS summary statistics GWASs Immunity Integrative analysis Interpretation mapped mechanism mechanisms metabolism phenotype Phenotypes profiles Randomized controlled trials reported Scientific community Secondary analyses subset traits unique variant variants [DOI] 10.1371/journal.pgen.1009713 PMC 바로가기 [Article Type] Research Article
The role of vitamin C in pneumonia and COVID-19 infection in adults with European ancestry: a Mendelian randomisation study Research Published on 2021-08-302022-10-05 Journal: European journal of clinical nutrition [Category] 유전자 메커니즘, 임상, 치료법, [키워드] Analysis applied approach association available data biological pathways circulating COVID-19 COVID-19 hospitalisation COVID-19 infection critically ill patients dose European Evidence genetic instrument Genome-wide association study GWAS High dose host genetics Infection lower risk MR-Egger patients patients with pneumonia plasma Pneumonia predicted provided randomisation Result severe COVID-19 shown Single nucleotide polymorphism SNPs Support susceptibility therapeutic effect treat Treatment Trial UK biobank Vitamin C weighted median were used with COVID-19 [DOI] 10.1038/s41430-021-00993-4 [Article Type] Research
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistanceArticle Published on 2021-06-072022-10-04 Journal: Nature Communications [Category] 변종, [키워드] antibiotic Antibiotic resistance Antibiotics antimicrobial antimicrobial agent antimicrobial resistance Antimicrobials approach Bacterial binding biological pathways catalytic combating develop Efficacy identify inhibit Metals molecular molecular mechanism molecular target MRSA offer Protein proteomics public health question silver Staphylococcus aureus susceptibility X-ray crystallography [DOI] 10.1038/s41467-021-23659-y PMC 바로가기 [Article Type] Article
Colonic Gangrene: A Sequela of Coronavirus Disease 2019Internal Medicine Published on 2021-04-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome Affect biological pathways bowel gangrene cause colectomy colonic constipation coronavirus coronavirus disease COVID-19 descending diagnosed discharged home disease dysregulation exaggerated immune response female Gastrointestinal symptom gastrointestinal system highlight Initially intestinal ischemia Laparotomy major organs manifestation multiple organs presenting Respiratory disease respiratory symptom SARS-CoV-2 sequela sigmoid colon small vessel vasculitis the patient treated Trigger [DOI] 10.7759/cureus.14687 PMC 바로가기 [Article Type] Internal Medicine
New Roles for Vitamin D Superagonists: From COVID to CancerEndocrinology Published on 2021-03-312022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, [키워드] agonist approach biological pathways changes in circumvent Control COVID COVID-19 detrimental Effect effective Effects Efficacy Gene Expression Immunity induce New Pancreatic cancer pancreatic stellate cell paricalcitol pathophysiology Patient patients with COVID-19 reduced resource role specificity superagonist the cytokine storm therapeutic therapeutic agents Vitamin D widespread [DOI] 10.3389/fendo.2021.644298 PMC 바로가기 [Article Type] Endocrinology
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagationArticle Published on 2020-03-302022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Analysis Antiviral antiviral strategy biological pathways biological processe Calu-3 Cell cells cellular change characterized circRNA Circular competing endogenous RNA demonstrated epithelial expression expression pattern Factor function group highly pathogenic Host host genes human lung in viral Infection investigated involved KEYWORDS: MERS-CoV knockdown MAPK MERS-CoV MERS-CoV infection metabolic processes Middle East miRNA modulate mRNA noncoding RNA Pathways perturbations predicted proportion Protein provided reaction recent reduced Regulatory required respiratory syndrome coronavirus reveal RNA selected significantly siRNA Specific Structure target mRNA targets unique Variation viral infections [DOI] 10.1080/22221751.2020.1738277 PMC 바로가기 [Article Type] Article